Most of our prescription medicines are administered orally or by injection. As a patient, the general preference is to receive medicine orally in pill or ‘syrup’ format. Indeed a phobia or fear of needles is common and with billions of injections given each year that’s a lot of nervous patients.
Injections pose other challenges too for patients and medical professionals. There is always a risk of infection caused by piercing the skin, especially from contaminated needles, and medical professionals need to be wary of ‘stick’ injuries.
But sometimes injections are unavoidable. Drugs made from large proteins can be broken down in the stomach before they can take effect. But what if there was a way to use the powerful acids in our stomachs to deliver an injection in the form of a pill – from the inside?
It seems implausible, but that’s what researchers at Massachusetts Institute of Technology (MIT) and Massachusetts General Hospital have managed to do.
If you’ve ever had a tropical aquarium there’s a good chance you’ll have owned and been delighted by the vibrant colours of a darting Zebrafish.
What you may not know is that the Zebrafish has become a firm favourite of the research community. One reason for this is that Zebrafish embryos are completely transparent making them ideally suited for studying developmental processes as they occur.
As a general introduction to why Zebrafish are so attractive to the science community, take a look at this YouTube video produced by University College London (UCL).